Curcumin (Longvida)
Four randomized, placebo-controlled trials have tested Longvida on cognition. Two from the same research group were positive at 400mg/day: in 60 healthy adults aged 60–85 (Cox et al., 2015), sustained attention and working memory improved 1 hour after a single dose, and working memory and mood after 4 weeks; in 80 adults aged 50–80 (Cox et al., 2020, funded by Longvida's maker Verdure Sciences), working memory was better at 12 weeks and fatigue lower at 4 and 12 weeks. Two trials funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences, gave 2000mg/day and found no cognitive benefit: 12 weeks in 39 healthy adults aged 45–74 (Santos-Parker et al., 2018) and 12 months in 88 adults with chronic kidney disease (Gimblet et al., 2024). The positive results have not been repeated by an independent group.
エビデンス確認日:
作用機序
Longvida is Verdure Sciences' trademarked solid lipid curcumin particle (SLCP) formulation of curcumin, the main active compound in turmeric (Curcuma longa). A 400mg dose of Longvida provides about 80mg of curcumin, so doses given as mg of Longvida and mg of curcumin differ about five-fold. Curcumin has properties in preclinical studies that may act on processes behind age-related cognitive decline, but those benefits had not been established in humans when the Longvida trials began; the trials measured cognitive and mood outcomes, not how they might arise.
臨床エビデンスの概要
Four randomized, placebo-controlled trials have tested Longvida on cognition. Two from the same research group were positive at 400mg/day: in 60 healthy adults aged 60–85 (Cox et al., 2015), sustained attention and working memory improved 1 hour after a single dose, and working memory and mood after 4 weeks; in 80 adults aged 50–80 (Cox et al., 2020, funded by Longvida's maker Verdure Sciences), working memory was better at 12 weeks and fatigue lower at 4 and 12 weeks. Two trials funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences, gave 2000mg/day and found no cognitive benefit: 12 weeks in 39 healthy adults aged 45–74 (Santos-Parker et al., 2018) and 12 months in 88 adults with chronic kidney disease (Gimblet et al., 2024). The positive results have not been repeated by an independent group.
ヒト効果マトリクス
Based on human clinical trials only. Animal and in-vitro data excluded.
| 効果 | エビデンス | 効果の大きさ | 研究数 |
|---|---|---|---|
| Working Memory | mixed | 小 | 4 |
| Fatigue & Mood | preliminary | 小 | 2 |
| Acute Attention | preliminary | 小 | 1 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
実証された効果
- Better working memory in healthy older adults at 400mg/day (two trials from one research group)
- Lower fatigue at 4 and 12 weeks (one trial)
- Better attention and working memory 1 hour after a single dose (one trial)
副作用と注意事項
- Fasting blood glucose was slightly higher than on placebo after 12 weeks in one trial (not in the diabetic range); the effect in people with diabetes has not been tested
- In a 12-month trial at 2000mg/day, abdominal pain was more common than on placebo (13% vs 5%, not statistically significant); no serious adverse event was attributed to curcumin
- Turmeric and curcumin supplements (not Longvida specifically) have been linked to rare cases of acute liver injury
- In a laboratory study on pig liver cells, curcumin changed the activity of enzymes that clear warfarin; ask a doctor before combining curcumin with an anticoagulant
摂取方法
スタッキングの推奨
Curcumin (Longvida)と相性の良い成分とその理由。
よくある質問
Is Longvida the same as turmeric or plain curcumin?
No. Longvida is a specific solid lipid curcumin formulation; 400mg of it provides about 80mg of curcumin. Trials of other curcumin products are not evidence for Longvida, and the Longvida trials are not evidence for them.
What dose was tested?
400mg of Longvida a day (about 80mg curcumin) in the two positive cognition trials. Two trials at 2000mg a day found no cognitive benefit, so a higher dose has not been shown to work better.
Who funded the research?
Verdure Sciences, which makes Longvida, funded the 2020 positive trial. The two trials that found no benefit were funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences. Both positive trials come from one research group and have not been repeated independently.
Is it safe?
The trials reported no serious adverse event attributed to curcumin. One trial found slightly higher fasting blood glucose after 12 weeks, so people with diabetes should ask a doctor first. Turmeric supplements have been linked to rare liver injury, and curcumin may interact with warfarin.
Curcumin (Longvida) in Japan
Products in Japan
None of the stacks we have audited are listed in our catalogue in Japan yet.
Consumer Affairs Agency (FFC)
Regulatory note
本ページは教育目的の編集コンテンツであり、医学的助言を構成するものではありません。日本国内で販売される機能性表示食品（FFC）および特定保健用食品（FOSHU）は、消費者庁への届出または許可を必要とします。届出のない輸入品については、日本の薬機法（旧薬事法）の下で疾病治療を示唆する表現は規制されます。サプリメントを開始する前に、必ず資格のある医療専門家にご相談ください。This page is editorial and not medical advice. Foods with Function Claims (FFC) and Foods for Specified Health Uses (FOSHU) sold in Japan require notification or approval from the Consumer Affairs Agency. Imported products without notification cannot make disease-treatment claims under the Pharmaceuticals and Medical Devices (PMD) Act. Note: In July 2026, the Consumer Affairs Agency (CAA) opened a public comment period (Notice No. 235080088, closes 30 July 2026) on proposed revisions to permitted claim wording for FFC-notified ingredients including DHA, phosphatidylserine, and NMN; compliant claim language may require updating once the final Cabinet Office Order is published. Consult a qualified healthcare professional before starting any supplement.
出典 (6)展開
- PMID 25277322Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population (2015)
- PMID 32512782Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study (2020)
- PMID 29951592Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults (2018)
- PMID 39199229Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial (2024)
- PMID 32656820Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports (2021)
- PMID 35695287Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity (2022)